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A transient breach in the epithelial barrier leads to the resistance to colitis This study was the first direct attempt to understand how physiologic breaks in the mucosal barrier, which must occur for homeostatic regulatory T cells to develop (Figure 1), may differ from the pathological mucosal barrier defects widely implicated in promoting inflammation of the underlying lamina propria
Without treatment, this leads to megaloblastic anaemia and potentially serious neurological complications
In wild-type and ob/ob mice, adiponectin heightens uncoupling protein 1 (UCP1, thermogenin) mRNA levels in BAT and encourages thermogenesis, without modifying food intake
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